Table 3.

Relationship between tumor response and the SII-PNI score

Tumor response	SII-PNI score(%)			p-value
& RECIST version 1.1 evaluation	0 (n = 44)	1 (n = 29)	2 (n = 27)
ORR	40(90.9)	20(69.0)	10(37.0)	<0.001
DCR	43(97.7)	27(93.1)	25(92.6)	0.511
# Pathologic TRG grading
TRG3 (n = 51)	3 (2.80)	15 (36.59)	33 (100.00)	<0.001
Non-TRG3 (n = 130)	104 (97.20)	26 (63.41)	0 (0)

Note SII, Systemic immune-inflammatory index; PNI, prognostic nutritional index; ORR=(CR + PR)/(CR + PR + SD + PD); DCR=(CR + PR + SD)/(CR + PR + SD + PD).CR is defined as the disappearance of all target lesions.PR is defined as a reduction of at least 30% in the sum of the target lesion diameters from the sum of the baseline diameters.PD is defined as a minimum increase in the sum of the target lesion diameters of at least 20% relative to the smallest sum of the diameters in the study.SD is defined as neither sufficient reduction to qualify for PR nor sufficient increase to qualify for PD. The target lesion was a measurable lymph node lesion with a short diameter of > 1.5 cm. The change in the sum of the diameters of all target lesions before and after neoadjuvant therapy was used to calculate the efficacy evaluation. &, evaluation of measurable lymph node lesions (short diameter > 1.5 cm) before and after neoadjuvant therapy; #, evaluation of primary lesions before and after neoadjuvant therapy