Table 4.
Multivariate analysis of the clinicopathological characteristics for the prognosis of LAGC patients
| Clinical variables | 5-year OS multivariate analysis | 5-year DFS multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | ||
| Age (years) | 0.872 | 0.639 | |||||
| < 60 | 1.000 | reference | 1.000 | reference | |||
| ≥ 60 | 1.063 | 0.632–1.872 | 1.203 | 0.764–1.897 | |||
| Surgical Procedures | 0.892 | 0.707 | |||||
| Laparoscopic | 1.000 | reference | 1.000 | reference | |||
| Laparotomy | 1.108 | 0.772–1.893 | 1.337 | 0.598–2.436 | |||
| Surgical resection | 0.632 | 0.703 | |||||
| Distal subtotal | 1.000 | reference | 1.000 | reference | |||
| Total | 1.232 | 0.835–1.678 | 1.114 | 0.704–1.697 | |||
| Proximal subtotal | 0.995 | 0.670–1.609 | 1.095 | 0.635–1.402 | |||
| Tumour size (cm) | 0.696 | 0.019 | |||||
| < 5.0 | 1.000 | reference | 1.000 | reference | |||
| ≥ 5.0 | 1.203 | 0.892–1.980 | 1.603 | 1.023–3.524 | |||
| Differentiation | 0.009 | 0.005 | |||||
| Poor | 1.000 | reference | 1.000 | reference | |||
| Moderately or well | 3.982 | 2.204–8.304 | 4.339 | 2.330–9.874 | |||
| Postoperative complication | 0.384 | 0.673 | |||||
| No | 1.000 | reference | 1.000 | reference | |||
| Yes | 1.203 | 0.837–2.430 | 1.338 | 0.675–1.980 | |||
| Clavien-Dindo classification | 0.763 | 0.772 | |||||
| I | 1.000 | reference | 1.000 | reference | |||
| II | 1.323 | 0.743–2.490 | 1.441 | 0.802–2.502 | |||
| III | 1.743 | 0.923–2.806 | 1.609 | 0.899–2.941 | |||
| ypTNM stage | 0.001 | 0.001 | |||||
| I and II | 1.000 | reference | 1.000 | reference | |||
| III | 5.992 | 2.098–13.911 | 6.546 | 2.242–15.923 | |||
| SII-PNI score | 0.001 | 0.001 | |||||
| 0 | 1.000 | reference | 1.000 | reference | |||
| 1 | 2.073 | 1.341–7.294 | 2.348 | 1.595–6.892 | |||
| 2 | 4.982 | 1.890-10.234 | 4.763 | 1.994–13.903 | |||
| Neoadjuvant chemotherapy | 0.772 | 0.834 | |||||
| XELOX | 1.000 | reference | 1.000 | reference | |||
| SOX | 1.098 | 0.893–2.009 | 1.131 | 0.721–1.993 | |||
| Intensity of neoadjuvant chemotherapy | 0.632 | 0.555 | |||||
| Standard | 1.000 | reference | 1.000 | reference | |||
| Decline | 1.055 | 0.892–1.988 | 1.227 | 0.756–2.432 | |||
| Tumor response | 0.003 | 0.008 | |||||
| Non-TRG3 | 1.000 | reference | 1.000 | reference | |||
| TRG3 | 3.992 | 1.493–9.223 | 3.709 | 1.324–10.893 | |||
| Postoperative adjuvant chemotherapy | 0.007 | 0.009 | |||||
| Yes | 1.000 | reference | 1.000 | reference | |||
| No | 2.989 | 1.290–7.874 | 2.876 | 1.182–6.653 | |||
| Intensity of postoperative adjuvant chemotherapy | 0.012 | 0.015 | |||||
| Standard | 1.000 | reference | 1.000 | reference | |||
| Decline | 1.755 | 1.002–3.183 | 1.890 | 1.145–3.624 | |||
Note SII, Systemic immune-inflammatory index; PNI, Prognostic nutritional index