Table 2.

Associations between immune cell traits and MASLD mediated by blood metabolite/metabolite ratios 

Immune cell traits	Blood metabolites/ metabolite ratios	Outcome	Mediated effect	P
Monocyte AC	Eicosenedioate (C20:1-DC) levels	MASLD	-0.00627(-0.0258, 0.0133)	0.530
CD14 + CD16- monocyte AC	Histidine to asparagine ratio	MASLD	-0.00569(-0.0219, 0.0105)	0.491
CD14 + CD16- monocyte AC	Eicosenedioate (C20:1-DC) levels	MASLD	-0.00528(-0.0248, 0.0143)	0.597
CD45RA + CD8br %T cell	Succinimide levels	MASLD	-0.0026(-0.0109, 0.00567)	0.538
CD14 + CD16- monocyte AC	Carnitine to ergothioneine ratio	MASLD	-0.00728(-0.0327, 0.0181)	0.574
CD14 + CD16- monocyte AC	Histidine to asparagine ratio	MASLD	-0.00569(-0.0219, 0.0105)	0.491

Abbreviation: MASLD Metabolic dysfunction associated steatotic liver disease