Table 2.
The inhibitory profiles of 6d and 7b against MMP-2, MMP-9, MMP-10, and MMP-13.
| Compound No. | MMP-9 |
MMP-2 | MMP-10 | MMP-13 | |
|---|---|---|---|---|---|
| % Inhibitiona (0.5 μM) |
IC50a (μM) |
% Inhibitiona (0.5 μM) |
% Inhibitiona (0.5 μM) |
% Inhibitiona (0.5 μM) |
|
| 6d | 96.2 ± 0.6 | 0.09 ± 0.01 | 40.6 ± 3.5 | 82.4 ± 1.6 | 35.8 ± 3.2 |
| 7b | 82.3 ± 1.7 | ND | 95.1 ± 1.3 | 81.8 ± 1.5 | Nil |
| NNGH | 56.8 ± 0.8 | 0.35 ± 0.01 | 60.9 ± 3.4 | 47.4 ± 0.8 | 51.2 ± 1.4 |
aData are presented as Mean ± SD, n = 2.