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. 2024 Jun 27;14(6):e083635. doi: 10.1136/bmjopen-2023-083635

Table 2. Target trough concentrations for empiric therapy.

ECOFF, Pseudomonas spp Minimum trough concentration (mg/L) Maximum trough concentration (mg/L) Maximumdose/24 hours
PIP: 16 mg/L 16–64 160 24 g
MEM: 2 mg/L 4–20 20 8 g
FEP: 8 mg/L 8–16 20 8 g

ECOFF, epidemiological cut-off value; FEPcefepimeFEP, cefepimeMEM, meropenemMEMmeropenemmg/L, milligram/litre; PIPpiperacillinPIP, piperacillin