Table 2. Target trough concentrations for empiric therapy.
ECOFF, Pseudomonas spp | Minimum trough concentration (mg/L) | Maximum trough concentration (mg/L) | Maximumdose/24 hours |
PIP: 16 mg/L | 16–64 | 160 | 24 g |
MEM: 2 mg/L | 4–20 | 20 | 8 g |
FEP: 8 mg/L | 8–16 | 20 | 8 g |
ECOFF, epidemiological cut-off value; FEPcefepimeFEP, cefepimeMEM, meropenemMEMmeropenemmg/L, milligram/litre; PIPpiperacillinPIP, piperacillin