Table 1.
Blood glucose, liver enzymes, and lipid profile, in wild-type and G6PDS188F rats fed with a high-fat diet for 8 months
| Blood content non-fasting | WT+NC | WT+HFD | G6PDS188F+NC | G6PDS188F+HFD |
|---|---|---|---|---|
| Glucose (mg/dl) | 367.2 ± 57.3 | 363.2 ± 45.4 | 332.4 ± 13.8 | 291.6 ± 13.1 |
| ALT (U/L) | 95.8 ± 18.0 | 73.5 ± 6.5 | 81.0 ± 9.0 | 65.2 ± 8.9 |
| AST (U/L) | 301.4 ± 28.0 | 295.2 ± 33.8 | 354.2 ± 90.2 | 289.6 ± 66.1 |
| T-Cholesterol (mg/dl) | 85.6 ± 16.2 | 111.7 ± 11.5 | 63.8 ± 6.0 | 86.4 ± 5.3a |
| Triglycerides (mg/dl) | 184.2 ± 38.5 | 160.5 ± 20.0 | 140.0 ± 9.3 | 126.0 ± 5.9 |
| HDL (mg/dl) | 50.6 ± 10.0 | 64.8 ± 9.6 | 32.8 ± 5.6 | 38.4 ± 4.9a |
| nHDLc (mg/dl) | 34.8 ± 6.2 | 46.8 ± 3.5b | 31.0 ± 2.6 | 48.2 ± 1.5c |
| LDL (mg/dl) | 3.4 ± 2.1 | 14.7 ± 2.3d | 5.0 ± 2.2 | 23.0 ± 0.6ca |
| VLDL (mg/dl) | 37.0 ± 7.7 | 32.0 ± 3.9 | 27.8 ± 1.9 | 25.2 ± 1.2 |
Mean ± SEM.
a
p < 0.05 versus WT+HFD.
b
p < 0.05 versus WT+NC or G6PDS188F.
c
p < 0.0005 versus WT+NC or G6PDS188F.
d
p < 0.005 versus WT+NC or G6PDS188F.