TABLE A4.
Characterisitic | Low (lowest tertile) | Medium | High (highest tertile) | P |
---|---|---|---|---|
No. (%) | 1,786 (33.3) | 1,786 (33.3) | 1,785 (33.3) | |
Age at diagnosis, median (IQR) | 52.5 (45.3-62.3) | 55.7 (47.3-63.6) | 56.2 (49.3-63.2) | <.001 |
Age at diagnosis, No. (%) | <.001 | |||
<40 | 182 (10.2) | 154 (8.6) | 87 (4.9) | |
40-49 | 543 (30.4) | 452 (25.3) | 411 (23.0) | |
50-59 | 503 (28.2) | 524 (29.3) | 644 (36.1) | |
60-69 | 408 (22.8) | 516 (28.9) | 516 (28.9) | |
≥70 | 150 (8.4) | 140 (7.8) | 127 (7.1) | |
Menopausal status, No. (%) | <.001 | |||
Premenopausal | 856 (48.8) | 741 (42.2) | 671 (38.3) | |
Postmenopausal | 897 (51.2) | 1,017 (57.8) | 1,082 (61.7) | |
Charlson Comorbidity Index, No. (%) | <.001 | |||
0 | 1,314 (79.8) | 1,364 (82.7) | 1,431 (86.7) | |
≥1 | 333 (20.2) | 285 (17.3) | 220 (13.3) | |
Breast cancer stage, No. (%) | <.001 | |||
I | 800 (45.2) | 899 (50.7) | 940 (53.2) | |
II | 763 (43.1) | 712 (40.1) | 672 (38.0) | |
III | 206 (11.6) | 163 (9.2) | 155 (8.8) | |
Breast cancer surgery type, No. (%) | .002 | |||
None | 1 (0.1) | 1 (0.1) | 0 (0.0) | |
Mastectomy | 524 (29.4) | 427 (23.9) | 437 (24.5) | |
BCS | 1,260 (70.6) | 1,356 (76.0) | 1,344 (75.5) | |
Lymph node management, No. (%) | <.001 | |||
SNLB only or none | 1,056 (59.1) | 1,142 (63.9) | 1,190 (66.7) | |
Axillary dissection or other | 730 (40.9) | 644 (36.1) | 595 (33.3) | |
Radiotherapy, No. (%) | .75 | |||
No | 145 (8.1) | 133 (7.4) | 141 (7.9) | |
Yes | 1,640 (91.9) | 1,653 (92.6) | 1,644 (92.1) | |
Chemotherapy type, No. (%) | <.001 | |||
None | 739 (41.4) | 838 (46.9) | 865 (48.5) | |
Adjuvant | 800 (44.8) | 745 (41.7) | 704 (39.5) | |
Neoadjuvant or both | 247 (13.8) | 203 (11.4) | 215 (12.1) | |
Endocrine therapy, No. (%) | <.001 | |||
TAM ± OFS | 549 (30.8) | 480 (26.9) | 421 (23.6) | |
AI ± OFS | 693 (38.8) | 763 (42.7) | 820 (46.0) | |
AI + TAM ± OFS | 241 (13.5) | 239 (13.4) | 228 (12.8) | |
None or OFS only | 301 (16.9) | 304 (17.1) | 315 (17.7) | |
Household adjusted income €, median (IQR) | 1,237 (884-1,375) | 2,013 (1,750-2,250) | 3,250 (2,750-4,000) | <.001 |
Educational level, No. (%) | <.001 | |||
Low | 984 (56.1) | 653 (36.9) | 285 (16.0) | |
Medium | 581 (33.1) | 740 (41.8) | 691 (38.9) | |
High | 190 (10.8) | 376 (21.3) | 801 (45.1) | |
Financial difficulties, No. (%) | <.001 | |||
High | 510 (29.0) | 113 (6.4) | 35 (2.0) | |
Medium | 553 (31.4) | 474 (26.7) | 137 (7.7) | |
Low | 697 (39.6) | 1,186 (66.9) | 1,598 (90.3) |
NOTE. Income refers to tertiles of household income per consumption unit. Financial difficulties defined according to how monthly household resources allowed participants to live: high (with difficulty), medium (adequately but on the limit), or low (financially comfortable). Educational level: high (high school and three or more years of higher education), medium (secondary school ± 2 years of professional training), and low (no education or primary education).
Abbreviations: AI, aromatase inhibitor; BCS, breast-conserving surgery; OFS, ovarian function suppression; SNLB, sentinel lymph node biopsy; TAM, tamoxifen.