. 2024 Aug 16;170(8):001488. doi: 10.1099/mic.0.001488

Table 1. Mycobacterium bovis BCG mutants with significantly altered survival upon exposure to rifampicin at 2 ng ml⁻¹ on Middlebrook 7H11 agar (Log2FC>1 or <-1, adjusted P value<0.05).

Gene locus	Gene name	Mtb H37Rv ortholog	Description	Log 2 FC	Adj P value
BCG_1782	pknE	Rv1743	Putative transmembrane serine/threonine-protein kinase E. Signal transduction	−2.15	<0.001
BCG_0012	–	Rv0012	Hypothetical protein	−1.65	0.018
BCG_1456	–	Rv1395	Transcriptional regulatory protein for Cyp132	−1.6	<0.001
BCG_3797	thrE	Rv3737	Putative transporter	−1.56	<0.001
BCG_1246 c	chp2	Rv1184c	Chp2 polyacyltrehalose synthesis	−1.12	<0.001
BCG_3331 c	glpD2_1	Rv3302c	Putative glycerol-3-phosphate dehydrogenase	−1.12	0.010
BCG_2672 c	–	Rv2660c	Hypothetical protein	−1.01	0.014
BCG_0258	–		Hypothetical protein	1.04	<0.001
BCG_2967 c	lppX	Rv2945c	Putative lipoprotein	1.04	0.035
BCG_0510 c	pcaA	Rv0470c	Mycolic acid synthase	1.06	<0.001
BCG_2941 c	amt	Rv2920c	Putative ammonium-transport integral membrane protein amt	1.06	0.018
BCG_2966	–	Rv2943A	Putative transposase	1.09	<0.001
BCG_3597 c	PPE62	Rv3533c	PPE family protein	1.09	0.025
BCG_0924 c	PE_PGRS15	Rv0872c	PE-PGRS family protein	1.14	<0.001
BCG_2996 c	–	Rv2974c	Hypothetical protein	1.15	<0.001
BCG_0356	–	Rv0316	Putative muconolactone isomerase	1.15	0.006
BCG_0218 c	–	Rv0181c	Hypothetical protein	1.15	0.022
BCG_2995 c	recG	Rv2973c	Putative atp-dependent DNA helicase, DNA repair	1.17	<0.001
BCG_3211	–	Rv3189	Hypothetical protein	1.17	<0.001
BCG_2977	–	Rv2956	Hypothetical protein	1.19	<0.001
BCG_2991 c	lipN	Rv2970c	Putative lipase/esterase	1.2	<0.001
BCG_2988 c	pca	Rv2967c	Pyruvate carboxylase, gluconeogenesis	1.21	<0.001
BCG_2971 c	fadD29	Rv2950c	Acyl-CoA synthetase, PGL synthesis	1.22	<0.001
BCG_2972 c	–	Rv2951c	Putative oxidoreductase	1.22	<0.001
BCG_2633	PPE42	Rv2608	PPE family protein	1.23	0.032
BCG_2984	–	Rv2963	Putative integral membrane protein	1.24	<0.001
BCG_2982	–	Rv2961	Putative transposase	1.25	<0.001
BCG_2975 c	–	Rv2954c	Hypothetical protein	1.26	<0.001
BCG_2983 c	–	Rv2962c	Putative glycosyl transferase	1.3	<0.001
BCG_2993	–	Rv2971	Putative oxidoreductase	1.3	0.018
BCG_2990 c	–	Rv2969c	Putative membrane or secreted protein	1.31	<0.001
BCG_2969 c	fadD22	Rv2948c	Acyl-CoA synthetase, PGL synthesis	1.32	<0.001
BCG_2968 c	pks1	Rv2946c	Putative polyketide synthase	1.34	<0.001
BCG_2994 c	–	Rv2972c	Putative membrane or exported protein	1.36	<0.001
BCG_2974	–	Rv2953	Hypothetical protein	1.38	<0.001
BCG_2979 c	–	Rv2958c	PGL/p-HBAD biosynthesis glycosyltransferase	1.38	<0.001
BCG_2989 c	–	Rv2968c	Putative integral membrane protein	1.42	<0.001
BCG_2973	–	Rv2952	Putative methyltransferase	1.5	<0.001
BCG_3899	–	Rv3836	Hypothetical protein	1.5	<0.001
BCG_2985	purU	Rv2964	Formyltetrahydrofolate deformylase, purine synthesis	1.54	<0.001
BCG_2976 c	–	Rv2955c	Hypothetical protein	1.57	<0.001
BCG_2980 c	–	Rv2959c	Putative methyltransferase	1.63	<0.001

Table 1. Mycobacterium bovis BCG mutants with significantly altered survival upon exposure to rifampicin at 2 ng ml−1 on Middlebrook 7H11 agar (Log2FC>1 or <-1, adjusted P value<0.05).

Table 1. Mycobacterium bovis BCG mutants with significantly altered survival upon exposure to rifampicin at 2 ng ml⁻¹ on Middlebrook 7H11 agar (Log2FC>1 or <-1, adjusted P value<0.05).