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. 2012 Apr 18;2012(4):CD003797. doi: 10.1002/14651858.CD003797.pub2

Comparison 1. Anticholinergic agents versus short‐acting beta2‐agonist.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Treatment failure 4 171 Odds Ratio (M‐H, Fixed, 95% CI) 2.27 [1.08, 4.75]
1.1 Ipratropium bromide versus beta2‐agonists 3 143 Odds Ratio (M‐H, Fixed, 95% CI) 2.36 [1.02, 5.47]
1.2 Atropine sulphate versus metaproterenol 1 28 Odds Ratio (M‐H, Fixed, 95% CI) 1.97 [0.42, 9.32]
2 Admission to hospital 3 139 Odds Ratio (M‐H, Fixed, 95% CI) 5.50 [1.11, 27.16]
2.1 Ipratropium bromide versus beta2‐agonist 2 111 Odds Ratio (M‐H, Fixed, 95% CI) 5.34 [0.24, 121.00]
2.2 Atropine sulphate versus metaproterenol 1 28 Odds Ratio (M‐H, Fixed, 95% CI) 5.57 [0.88, 35.27]
3 PEF @ 30 minutes (% predicted) 2   Mean Difference (IV, Fixed, 95% CI) Totals not selected
3.1 Ipratropium bromide versus salbutamol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
3.2 Atropine sulphate versus metaproterenol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
4 PEF @ 120 minutes (% predicted) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
4.1 Ipratropium bromide versus salbutamol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
5 FEV1 @ 30 minutes (litres/sec) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.1 Ipratropium bromide versus fenoterol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 FEV1 @ 30 minutes (% predicted) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
6.1 Oxitropium bromide versus fenoterol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
7 FEV1 @120 minutes (litres/sec) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
7.1 Ipratropium bromide versus fenoterol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
8 Pulmonary index @ 30 mins 2   Mean Difference (IV, Fixed, 95% CI) Totals not selected
8.1 Ipratropium bromide versus fenoterol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.2 Atropine sulfate versus metaproterenol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
9 Pulmonary index @ 120 mins 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
9.1 Ipratropium bromide versus fenoterol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]