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. 2012 Apr 18;2012(4):CD003797. doi: 10.1002/14651858.CD003797.pub2

Comparison 2. Anticholinergic agents versus anticholinergics plus short‐acting beta2‐agonists.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Treatment failure 4 173 Odds Ratio (M‐H, Fixed, 95% CI) 2.65 [1.20, 5.88]
1.1 Ipratropium bromide versus ipratropium bromide plus beta2‐agonist 3 144 Odds Ratio (M‐H, Fixed, 95% CI) 3.67 [1.41, 9.50]
1.2 Atropine sulphate versus atropine sulphate plus metaproterenol 1 29 Odds Ratio (M‐H, Fixed, 95% CI) 1.02 [0.21, 4.98]
2 Admission to hospital 3 141 Odds Ratio (M‐H, Fixed, 95% CI) 5.90 [1.20, 29.05]
2.1 Ipratropium bromide versus ipratropium bromide plus beta2‐agonist 2 112 Odds Ratio (M‐H, Fixed, 95% CI) 5.69 [0.25, 128.50]
2.2 Atropine sulfate versus atropine sulfate plus metaproterenol 1 29 Odds Ratio (M‐H, Fixed, 95% CI) 6.0 [0.95, 37.76]
3 Participants requiring no repeat nebulisation 1   Odds Ratio (M‐H, Fixed, 95% CI) Totals not selected
3.1 Moderate‐severe acute asthma 1   Odds Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4 PEF @ 30 minutes (% predicted) 2   Mean Difference (IV, Fixed, 95% CI) Totals not selected
4.1 Ipratropium bromide versus ipratropium bromide plus salbutamol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.2 Atropine sulphate versus atropine sulphate plus metaproterenol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
5 PEF @ 120 minutes (% predicted) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
5.1 Ipratropium bromide versus ipratropium bromide plus salbutamol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 FEV1 @ 30 minutes (litres/sec) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
6.1 Ipratropium versus ipratropium bromide plus fenoterol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
7 FEV1 @120 mins (litres/sec) 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
7.1 Ipratropium versus ipratropium bromide plus fenoterol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
8 Pulmonary index @ 30 mins 2   Mean Difference (IV, Fixed, 95% CI) Totals not selected
8.1 Ipratropium bromide versus ipratropium bromide plus fenoterol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
8.2 Atropine sulfate versus atropine sulfate plus metaproterenol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
9 Pulmonary index @ 120 mins 1   Mean Difference (IV, Fixed, 95% CI) Totals not selected
9.1 Ipratropium bromide versus ipratropium bromide plus fenoterol 1   Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]