Guill 1987.

Methods	Randomised double‐blind parallel group trial. Method of randomisation: computer‐generated random numbers table Emergency department or outpatient setting
Participants	N = 35 with 44 episodes of acute asthma (Group 1: 15; Group 2: 13; Group 3: 16) 26 M/18 F; age range: 13 months to 13 years
Interventions	All treatments were administered via a Hudson 1700 updraft nebuliser and paediatric face mask attached with standard oxygen tubing to a Pulmo‐Aid compressor Group 1: metaproterenol 5% (50,000 mcg/mL), 0.2 mL (10,000 mcg) in < 12 years; 0.3 mL (15,000 mcg) ≥ 12 years in 2 mL normal saline Group 2: atropine sulfate 0.05 to 0.1 mg/kg, max 2.0 mg i.e. 500 to 1000 mcg/kg in 2 mL normal saline Group 3: metaproterenol + atropine sulfate (same dosage as above) Three doses of nebulised medicines were administered 20 to 30 minutes apart
Outcomes	Severity of bronchospasm as assessed by a pulmonary index score (0 to 12) at entry and 20 minutes after each inhalation PEF measure at entry and at 20 minutes after each inhalation (in patients old enough to perform manoeuvre) Number of treatments and treatment failure
Notes	Computer generated random numbers were used for each episode rather than for individual patients
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer generated random numbers
Allocation concealment (selection bias)	Low risk	Randomly assigned in a double‐blind manner
Blinding (performance bias and detection bias) All outcomes	Low risk	Double‐blinded