Table 1.

Study Cohort Characteristics

	C-ALD (n = 38)	NL-ALD (n = 14)
Age at initial scan, y, mean (SD); range	8.2 (2.8); 4.7–14.9	8.0 (3.7); 3.3–14.0
Age at follow-up scan, y, mean (SD); range	9.3 (2.8); 5.8–15.6	9.1 (3.8); 4.2–15.0
Radiologic severity, mean (SD); range
Loes MRI score at initial scan	5.5 (4.7); 1–19	0
Loes MRI score at follow-up scan	8.3 (6.0); 1.5–23	0
Demyelination pattern, n
Parietal-occipital variant	32/38	N/A
Frontal variant	2/38	N/A
Atypical variant (no callosal lesion)	4/38	N/A

Abbreviations: C-ALD = cerebral adrenoleukodystrophy; NL-ALD = adrenoleukodystrophy with no lesion.