Table 3.

Correlations between PRO measures and validity indicators at baseline

PRO measure	Validity indicator
	VAS	Productivity
FACT-B trial outcome index	0.641 P < .001 n= 73	0.613 P < .001 n = 755
PROMIS fatigue	−0.523 P < .001 n = 727	—
PROMIS anxiety	−0.408 P < .001 n = 734	—
PROMIS ability to participate in social roles and activities	0.593 P < .001 n = 730	—
PRO-CTCAE severity of shortness of breath at its worst	—	−0.191 P < .001 n = 751
PRO-CTCAE shortness of breath interferes with usual activities	—	−0.260 P < .001 n = 727
PRO-CTCAE frequency of chest pain, chest tightness, or angina	—	−0.199 P < .001 n = 751
PRO-CTCAE severity of chest pain, chest tightness, or angina at its worst	—	−0.210 P < .001 n = 724
PRO-CTCAE chest pain, chest tightness, or angina interferes with usual activities	—	−0.230 P < .001 n = 725

—: no associations between variables were expected or evaluated. For FACT-B, higher scores represent better health-related quality of life. For PROMIS, higher scores represent more of the outcome, eg, more fatigue, more anxiety, better ability. VAS ranges from 0 (worst imaginable health) to 100 (best imaginable health). Productivity represents a single item that assesses the extent that a patient was able to resume normal activities.

Abbreviations: FACT-B = Functional Assessment of Cancer Therapy-Breast; PRO = patient-reported outcome; PRO-CTCAE = Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events; PROMIS = Patient-Reported Outcomes Measurement Information System; VAS = Visual Analog Scale from the EQ-5D.