Table 1.
Characteristics, baseline complete blood parameters, and inflammatory markers of the participants.
| Characteristics | MDD patients (n = 139) | Healthy controls (n = 54) | P-value |
|---|---|---|---|
| Sex, n (%) | 0.688 | ||
| Male | 42 (30.22) | 19 (35.19) | |
| Female | 97 (69.78) | 35 (64.81) | |
| Age (years) | 0.916 | ||
| Mean ± SD | 20.44 ± 1.13 | 20.42 ± 1.32 | |
| BMI | 0.643 | ||
| Mean ± SD | 22.69 ± 6.07 | 23.03 ± 3.92 | |
| State of depressive episode, n (%) | – | ||
| First episode | 127 (91.37) | – | |
| Recurrent depression | 12 (8.63) | – | |
| Suicide risk score (8Q score), n (%) | < 0.0001* | ||
| No suicide risk (score = 0) | 59 (42.45) | 54 (100.00) | |
| Low suicide risk (score = 1–16) | 56 (40.29) | 0 (0.00) | |
| High suicide risk (score ≥ 17) | 24 (17.26) | 0 (0.00) | |
| WBC count (× 109 cells/L) | 7.91 ± 2.15 | 6.91 ± 1.45 | 0.002* |
| Neutrophil (%) | 60.56 ± 6.06 | 54.52 ± 4.82 | < 0.0001* |
| Neutrophil count (× 109 cells/L) | 4.82 ± 1.54 | 3.77 ± 0.85 | < 0.0001* |
| Lymphocyte (%) | 32.09 ± 5.53 | 37.20 ± 3.84 | < 0.0001* |
| Lymphocyte count (× 109 cells/L) | 2.51 ± 0.72 | 2.57 ± 0.61 | 0.585 |
| Monocyte (%) | 5.33 ± 2.74 | 5.69 ± 2.13 | 0.342 |
| Monocyte count (× 109 cells/L) | 0.41 ± 0.23 | 0.39 ± 0.16 | 0.476 |
| Platelet count (× 109 cells/L) | 290.27 ± 67.31 | 263.37 ± 43.55 | 0.001* |
| NLR | 2.00 ± 0.72 | 1.49 ± 0.26 | < 0.0001* |
| MLR | 0.172 ± 0.096 | 0.156 ± 0.061 | 0.162 |
| PLR | 122.78 ± 39.22 | 106.19 ± 23.16 | < 0.0001* |
| SII (109 cells/L) | 573.66 ± 221.46 | 389.40 ± 78.25 | < 0.0001* |
| SIRI (109 cells/L) | 0.81 ± 0.51 | 0.58 ± 0.24 | < 0.0001* |
Data are shown as mean ± SD, unless otherwise noted. *P < 0.05.
MDD major depressive disorder, n number of patients, BMI body mass index, 8Q score depression scale from the 8Q Scale, WBC white blood cell, NLR neutrophil-to-lymphocyte ratio, MLR monocyte-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, SII systemic immune-inflammatory index, SIRI systemic inflammation response index.