Table 1.
Characteristics of study participants
| PSP (n = 1,718) | Control (n = 2,944) | ||
|---|---|---|---|
|
Autopsy Confirmed (n = 1,441) |
Clinical Diagnosed (n = 277) |
||
| Female | 625 (43%) | 129 (46%) | 1,775 (60%) |
| Age, y (SD) | 68.38 (8.22) | 65.72 (7.68) | 81.19 (6.01) |
| AF of APOE ε4a | 13% | 11% | 17% |
| ε4 carriers | 350 (24%) | 57 (21%) | 905 (32%) |
| Non-ε4 carriers | 1,085 (75%) | 216 (78%) | 1,913 (65%) |
| Data missing | 6 (0.42%) | 4 (1%) | 126 (4%) |
| AF of APOE ε2b | 9% | 7% | 4% |
| ε2 carriers | 234 (16%) | 36 (13%) | 220 (8%) |
| Non-ε2 carriers | 1,193 (83%) | 238 (86%) | 2,522 (86%) |
| Data missing | 14 (1%) | 3 (1%) | 202 (7%) |
| AF of H2c | 6% | 5% | 23% |
| H2 carriers | 158 (11%) | 27 (10%) | 1,182 (40%) |
| Non-H2 carriers | 1,283 (89%) | 250 (90%) | 1,761 (60) |
| Data missing | 0 (0%) | 0 (0%) | 1 (0.03%) |
SD Standard deviation, AF Allele frequency
aAPOE ε4 is represented by the genotypes of rs429358-C
bAPOE ε2 is represented by the genotypes of rs7412-T
cH2 haplotype is determined by the genotypes of rs8070723-G