Table 2.

Top associations from genome-wide association study

SNV	Chr	Position	Ref	Alt	AF (Alt)	β (Alt)	P	Gene	eQTL/sQTL
Genome-Wide Significance (P < 5 × 10−8)
rs62057121	17	45823394	G	A	0.15	-1.32	7.45 × 10–78	MAPT	LRRC37A4Pc*
rs4420638	19	44919689	A	G	0.20	-0.57	2.91 × 10–19	APOE	TOMM40b
rs7412	19	44908822	C	T	0.06	0.87	9.57 × 10–16	APOE
rs11708828	3	39458158	C	T	0.46	-0.35	7.04 × 10–12	MOBP	PRSAc
rs10753232	1	180980990	C	T	0.44	0.31	6.79 × 10–10	STX6	STX6a*
Loci of Potential Interest (P < 1 × 10−6)
rs56251816	19	17750888	A	G	0.22	0.35	6.57 × 10–08	FCHO1/MAP1S
rs12817984	12	53410523	T	G	0.16	-0.37	8.91 × 10–08	SP1	SP1a*
rs4712314	6	17833813	G	T	0.51	0.27	2.37 × 10–07	KIF13A
rs74651308	12	21323155	G	A	0.07	0.51	2.86 × 10–07	SLCO1A2
rs111593852	7	138449166	C	T	0.02	0.87	3.75 × 10–07	TRIM24
rs367364	6	32052169	C	T	0.13	-0.37	7.07 × 10–07	TNXB	CYP21A1Pc*
rs839764	1	43367703	T	A	0.41	0.27	7.94 × 10–07	ELOVL1	TIE1a*
rs12026659	1	221976623	G	A	0.21	0.31	9.48 × 10–07	DUSP10

Chr Chromosome, Ref Reference allele, Alt Alternative allele, AF Allele frequency

^*Represents the SNV regulates multiple genes, and the gene with the smallest P-value was shown here (eQTL/sQTL for the brain region was obtained through GTEx)

^aSNVs with significant eQTL hits

^bSNVs with significant sQTL hits

^cSNVs with both eQTL and sQTL hits