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. 2024 Jun 14;11(8):2016–2029. doi: 10.1002/acn3.52121

Table 5.

Cox proportional hazard model statistics for ESS and regional brain OLE (HR O) in post‐COVID patients.

Z‐score 95% CI Hazard ratio p‐value
Age 2.985 1.145–1.922 1.484 2.84e‐3*
Sex 2.034 1.164–3.548e3 64.27 0.042*
Brainstem −2.671 0.011–0.499 0.074 7.56e‐3*
Deep grey matter 2.272 1.813–3.226e3 76.48 0.023*
Amygdala 1.724 0.968–1.652 1.265 0.085
Nucleus accumbens −2.621 0.570–0.922 0.725 8.77e‐3*
Hippocampus −0.795 0.520–1.319 0.828 0.427
Thalamus −1.599 0.307–1.127 0.588 0.110
Globus pallidus 1.050 0.772–2.355 1.348 0.294
Putamen −2.518 0.210–0.823 0.416 0.012*
Caudate nucleus −0.577 0.631–1.285 0.901 0.563
Total white matter 1.440 0.902–1.960 1.330 0.150
Cortical grey matter −2.855 0.167–0.717 0.346 4.30e‐3*

Note that p‐values are not adjusted for multiple comparisons for false discovery rate in this table. Bolded text indicates statistically significant associations (*p < 0.05).

CI, confidence interval; ESS, Epworth Sleepiness Scale; HR O, hazard ratio calculated from Cox proportional hazard models using only OLE metrics; OLE, oxygen level estimate.