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. 2024 Aug 13;17:5311–5326. doi: 10.2147/JIR.S472341

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© 2024 Jiang et al.

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HJD alleviates pain in a dose-dependent manner. (A) Paw withdrawal mechanical threshold, (B) paw withdrawal thermal latency, and (C) hind limb weight distribution in rats from each group. (D-F) Immunohistochemical detection of CGRP and TRPV1 in the DRG of each. (G-I) Western blot analysis of CGRP and TRPV1 levels in the DRG. Inter-group differences were assessed using two-way repeated ANOVA with Bonferroni corrections. ^##p<0.01 vs Normal group, *p<0.05 vs KOA group, **p<0.01 vs KOA group.