Figure 4.

IL-1R signaling molecules are up-regulated in graft and PBMC samples following transplantation leading to a pro-inflammatory response. Statistically significant alterations in gene expression from RNAseq analysis of graft tissues are represented by red (up-regulation) and blue (down-regulation). Molecules which did not meet statistical significance, or for which mapping was unavailable in the rat genome are shown in white. FDR-p<0.05. FDR-corrected p-values and Cohort 2 versus Cohort 1 ratios are listed in Table 3.