Table 1.
Disease Characteristics and Neuropathology Features
| PPA Variant | Age at onset | Age at death | Duration (yr.) | Femalea (total) | Education (yr.) | ApoE4 carrier (n=68) | Braak NFT stage (n=72) | Thal amyloid phase (n=44) | CERAD score (n=77) | Brain weight (g) (n=56) |
|---|---|---|---|---|---|---|---|---|---|---|
|
Logopenic (n=35) |
63 (13) | 74 (12) | 9 (4.1) | 12 (34) | 16 (4) | 17/27 (63) | VI (1) | 5 (1.5) | 3 (0) | 1101 (301) |
|
Agrammatic (n=28) |
64 (14) | 72.6 (14) | 8.2 (3.8) | 12 (43) | 14 (4) | 3/25 (12) | II (1.5) | 0 (2) | 0 (0) | 1094 (277) |
|
Semantic (n=18) |
61 (11) | 71 (9) | 10 (5) | 7 (39) | 15.5 (2) | 6/15 (40) | 1 (2) | 0.5 (3) | 0 (0.5) | 1046 (118) |
| p. value | ns | ns | ns | ns | ns | <0.001 a | <0.001 | <0.001 | <0.001 | ns |
Median (IQR); for sex, ApoE4 n (%).
P. values are based on Kruskal-Wallis H test. One unclassifiable-PPA patient was excluded from analyses.
a
For sex, ApoE4 p. value is based on Fisher’s Exact.
*
P < 0.05.
PPA: Primary Progressive Aphasia.