Several primary hyperlipidemias (i.e., familial combined hyperlipidemias, familial hypertriglyceridemia, and dysbetalipoproteinemia) are associated with a higher risk of having type 2 diabetes (T2D).

Familial hypercholesterolemia patients have a lower prevalence of T2D than the general population.

The association between multifactorial chylomicronemia and T2D varies between 25 and 76%.

There is an inverse relationship between Lipoprotein (a) and T2D, but those with T2D and high levels of lipoprotein (a) have more risk for cardiovascular events.

The interaction between primary hyperlipidemias and T2D has not been addressed in clinical guidelines.