Table 2.
Distribution of clonal hematopoiesis of indeterminate potential (CHIP)-related mutations.
| (n=563) | (n=51) | (n=512) | Value | |
|---|---|---|---|---|
| DNMT3A, n(%) | 203 (36.1) | 28 (54.9) | 175 (34.2) | <0.01* |
| TET2, n(%) | 125 (22.2) | 10 (19.6) | 115 (22.5) | 0.73 |
| ASXL1, n(%) | 135 (24.0) | 11 (21.6) | 124 (24.2) | 0.73 |
| JAK2, n(%) | 37 (6.6) | 3 (5.9) | 34 (6.6) | 1.00 |
| TP53, n(%) | 116 (20.6) | 10 (19.6) | 106 (20.7) | 1.00 |
| SF3B1, n(%) | 22 (9.7) | 1(2.0) | 21(4.1) | 0.71 |
| SRSF2, n(%) | 57(10.1) | 3(5.9) | 54(10.5) | 0.46 |
| Presence of CHIP-related mutation, n(%) | 445(79.0) | 45(88.2) | 400(78.1) | 0.11 |
| Presence of ≥2 CHIP-related mutations, n(%) | 197(35.0) | 18(35.3) | 179(35.0) | 1.00 |
CHIP: clonal hematopoiesis of indeterminate potential; P value: compared between patients with and without HF;
* :
The p value corrected by Bonferroni adjustment is 0.021.