Table 4.

Cox proportional hazard analysis of the baseline characteristics associated with heart failure.

	Univariable		Multivariable regression Model 1		Multivariable regression Model 2 (age and anthracycline adjusted)
	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
Age	1.02(1.00–1.04)	0.06			1.01(0.99–1.04)	0.38
Hypercholesterolemia	2.36(1.33–4.19)	<0.01
Hypertension	2.53(1.44–4.43)	<0.01
≥2 CV risk factors*	2.17(1.22–3.87)	0.01	2.33(1.30–4.18)	<0.01	2.16(1.18–3.96)	0.01
Coronary heart disease	2.69(1.33–5.42)	0.01	2.02(0.96–4.25)	0.06	1.95(0.92–4.15)	0.08
Anthracycline dose	1.00(1.00–1.00)	0.83			1.14(0.37–3.46)	0.82
DNMT3A mutations	2.38(1.36–4.16)	<0.01#	2.50(1.42–4.18)	<0.01	2.32(1.26–4.29)	0.01

^{* :}CV risk factors include obesity, hypertension, hypercholesterolemia and diabetes.

^{# :}The p value corrected by Bonferroni adjustment is 0.014