Table 6.
One-year Cumulative Incidence and Risk of Cardiovascular Disease
| 1-year cumulative incidence of HF, % | Unadjusted | Adjusted* | |||
|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | ||
| Model 1 | |||||
| No hypertension | |||||
| No DNMT3A | 3.31 | 1[Reference] | NA | 1[Reference] | NA |
| DNMT3A | 6.62 | 1.46(0.70–3.04) | 0.31 | 1.49(0.70–3.20) | 0.30 |
| Hypertension | |||||
| No DNMT3A | 5.09 | 1.14(0.49–2.66) | 0.77 | 1.02(0.38–2.74) | 0.97 |
| DNMT3A | 25.49 | 5.74(2.84–11.64) | <0.001 | 4.91(2.35–10.29) | <0.001 |
| Model 2 | |||||
| No hypercholesterolemia | |||||
| No DNMT3A | 3.72 | 1[Reference] | NA | 1[Reference] | NA |
| DNMT3A | 6.52 | 1.32(0.65–2.67) | 0.44 | 1.39(0.65–2.95) | 0.39 |
| Hypercholesterolemia | |||||
| No DNMT3A | 4.44 | 0.82(0.31–2.21) | 0.70 | 0.67(0.23–1.93) | 0.46 |
| DNMT3A | 26.53 | 5.52(2.81–10.84) | <0.001 | 4.54(2.09–9.89) | <0.001 |
| Model 3 | |||||
| No obesity | |||||
| No DNMT3A | 3.69 | 1[Reference] | NA | 1[Reference] | NA |
| DNMT3A | 9.88 | 1.95(1.05–3.65) | 0.04 | 2.00(1.05–3.81) | 0.04 |
| Obesity | |||||
| No DNMT3A | 3.99 | 0.64(0.34–1.72) | 0.38 | 0.50(0.18–1.45) | 0.20 |
| DNMT3A | 15.87 | 2.46(1.07–5.66) | 0.03 | 2.38(1.04–5.43) | 0.04 |
| Model 4 | |||||
| No ≥2 CV risk factors# | |||||
| No DNMT3A | 3.51 | 1[Reference] | NA | 1[Reference] | NA |
| DNMT3A | 7.00 | 1.51(0.76–2.99) | 0.24 | 1.50(0.73–3.08) | 0.28 |
| ≥2 CV risk factors | |||||
| No DNMT3A | 4.90 | 0.89(0.35–2.24) | 0.80 | 0.95(0.38–2.35) | 0.91 |
| DNMT3A | 26.67 | 5.31(2.59–10.86) | <0.001 | 5.52(2.50–12.19) | <0.001 |
| Model 5 | |||||
| No prior coronary artery disease | |||||
| No DNMT3A | 2.38 | 1[Reference] | NA | 1[Reference] | NA |
| DNMT3A | 9.52 | 1.99(1.01–3.65) | 0.03 | 1.93(1.05–3.54) | 0.04 |
| Prior coronary artery disease | |||||
| No DNMT3A | 4.10 | 1.16(0.35–3.83) | 0.80 | 1.28(0.37–4.38) | 0.70 |
| DNMT3A | 25.00 | 5.61(2.37–13.26) | <0.001 | 5.51(2.27–13.42) | <0.001 |
| Model 6 | |||||
| No prior CV diseases@ | |||||
| No DNMT3A | 2.27 | 1[Reference] | NA | 1[Reference] | NA |
| DNMT3A | 8.67 | 1.68(0.89–3.17) | 0.11 | 1.61(0.83–3.13) | 0.16 |
| Prior CV diseases | |||||
| No DNMT3A | 4.44 | 0.66(0.23–1.90) | 0.44 | 0.68(0.24–1.93) | 0.47 |
| DNMT3A | 21.95 | 4.21(1.95–9.10) | <0.001 | 4.06(1.84–8.95) | <0.001 |
HF: heart failure; HR: hazard ratio;
All models were adjusted for age, sex and anthracycline doses. Additionally, model 1 was adjusted for hypercholesterolemia, diabetes and obesity; model 2 was adjusted for hypertension, diabetes and obesity; model 3 was adjusted for hypertension, diabetes and hypercholesterolemia;
CV risk factors include obesity, hypertension, hypercholesterolemia and diabetes;
CV diseases include coronary artery disease, atrial fibrillation/flutter, cerebrovascular disease, and peripheral artery disease; In this study cohort, the number of cases of diabetes, atrial fibrillation/flutter, cerebrovascular disease, chronic renal disease and peripheral artery disease was insufficient to stratify the risk of HF of the individual variables.