Table 4.
The top 20 KDGs identified using the KDA with both the DEG and Literature lists are presented below, and references are provided for genes with documented literature in the context of RA.
| Gene | KDA†
(Lit-DEG) |
Reference | Gene | KDA†
(Lit-DEG) |
Reference |
|---|---|---|---|---|---|
| PTPN6 | 12 - 12 | (69) | CASP1 | 11 - 11 | (70) |
| HLA-E | 12 - 11 | (71) | HLA-B | 12 - 10 | (71) |
| HLA-F | 12 - 11 | (71) | HLA-C | 12 - 10 | (71) |
| GBP1 | 12 - 11 | (72) | CD44 | 12 - 10 | (73) |
| LCP2 | 12 - 11 | (74) | IFI30 | 12 - 10 | None |
| GLIPR1 | 11 - 11 | None | TNFAIP8 | 12 - 10 | (75) |
| HLA-A | 11 - 11 | (71) | CCL5 | 12 - 10 | (76) |
| CTSS | 11 - 11 | (77) | PSMB8 | 12 - 10 | (78) |
| SRGN | 11 - 11 | None | TAP1 | 12 - 10 | (79) |
| CTSH | 11 - 11 | None | ICAM1 | 12 - 10 | (80) |
Genes also identified in GWAS are highlighted in bold. The complete list of the top 100 KDGs is available in Supplementary Section C . †The left (right) number corresponds to the number of networks the TF was identified as a KDG with the literature (DEG) list (adjusted ).