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. 2024 Aug 5;15:1444117. doi: 10.3389/fphar.2024.1444117

FIGURE 2.

FIGURE 2

COT extract and CEL attenuated hepatic steatosis and metabolic dysfunction in HFD-fed mice. (A) Experiment design used to evaluate the role of COT extract and CEL against NAFLD; (B) Body weight recorded every week; (C) Liver weight and (D) visceral adiposity index at the end of the experiment; (E) Representative images of HE- and ORO-stained liver sections (×400 magnification, scale bar = 50 μm); (F–I) AST and ALT levels in livers and serum; (J–L) Levels of TG, TC and LDL-C in livers and/or serum (n = 8); (M) Blood glucose levels in OGTT (n = 6); (N) Summary of area under the curve (AUC) of the OGTT. Data are represented as mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001 vs. the CON group; # P < 0.05, ## P < 0.01, and ### P < 0.001 vs. the MOD group; & P < 0.05 and &&& P < 0.001 vs. the CL group; ▽ P < 0.05 and ▽▽ P < 0.05 vs. the EL group.