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. 2024 Aug 5;15:1444117. doi: 10.3389/fphar.2024.1444117

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Copyright © 2024 Xue, Liu, Liu, Jia, Fang, Qin and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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COT extract and CEL improved the structure and function of liver mitochondria during NAFLD induced by HFD feeding in mice. (A) Representative TEM images of mouse hepatocytes, M represents the mitochondria, while N represents the nucleus (×2 k magnification, scale bar = 2 μm); Activity of (B) Na⁺/K⁺ ATPases (C) Mg²⁺ ATPases and (D) Ca²⁺ ATPases in liver tissue (n = 8); (E) liver ATP content (n = 3). Data are represented as mean ± SD. ***P < 0.001 vs. the CON group; ^# P < 0.05, ^## P < 0.01, and ^### P < 0.001 vs. the MOD group; ^& P < 0.05, ^&& P < 0.05, and ^&&& P < 0.001 vs. the CL group.