TABLE 2.

Differing experimental conditions in studies that injected a cannabinoid directly to the hypothalamus.

Species	Sex	CB1R agonist	Route	Energy status	Dose	Feed	Circadian	Outcome	References
Rats	Male	2AG	LHA	ad lib	1.2 μg	Rodent Laboratory Chow	Dark cycle	No effect	Sanchez‐Fuentes et al. 49
Rats	Male	d9‐THC	PVH	ad lib	5 μg	Standard chow (Rat and mouse chow, Ridley AgriProducts, Australia)	Dark cycle	Hyperphagia	Verty et al. 74
Rats	Male	ACEA	PVH	21 h fasted	0.25 μg	Standard rodent chow (LabDiet #5008)	Dark cycle	Hyperphagia	Cruz‐Martinez et al. 75
Rats	Male	AEA	VMH	Sated	50 ng	Standard rodent chow (ARM pellets)	Mid‐light cycle	Hyperphagia	Jamshidi and Taylor 101
Mice	x	ACEA	ARH	x	x	Standard rodent chow	Mid‐light cycle	Hyperphagia	Koch et al. 29
Rats	Female	d9‐THC (l isomer)	VMH	ad lib	0.25 μg	Purina Lab Chow	x	Hyperphagia	Anderson‐Baker et al. 32
Rats	Female	d9‐THC (l isomer)	LHA	ad lib	0.125, 0.25 μg	Purina Lab Chow	x	No effect	Anderson‐Baker et al. 32
Rats	Female	d9‐THC (d isomer)	VMH	ad lib	0.25 μg	Purina Lab Chow	x	Reduced intake	Anderson‐Baker et al. 32
Rats	Female	d9‐THC (d isomer)	LHA	ad lib	0.25 μg	Purina Lab Chow	x	Hyperphagia	Anderson‐Baker et al. 32
Rats	Male	AEA	PVH	ad lib	100, 400 pmol	Standard rodent chow	Dark cycle	Hyperphagia	Chapman et al. 76
Rats	Male	RIM	PVH	ad lib	0.03, 0.3, 3.0 μg	Standard chow (Rat and mouse chow, Ridley AgriProducts, Australia)	Dark cycle	No effect	Verty et al. 74
Rats	Male	AM251	PVH	ad lib	1.6 μg	Standard rodent chow	Mid‐light cycle	Reduced intake	Soria‐Gomez et al. 77
Rats	Male	AM251	PVH	24 h fasted	1.6 μg	Standard rodent chow	Dark cycle	Hyperphagia a	Soria‐Gomez et al. 77
Rats	Male	RIM	VMH	Sated	30 μg	Standard rodent chow (ARM pellets)	Mid‐light cycle	No effect	Jamshidi and Taylor 101
Mice	x	RIM	ARH	Fasted overnight	3 mg/kg	Standard rodent chow	Mid‐light cycle	Reduced intake	Koch et al. 29
Rats	Male	AM251	PVH	ad lib	5, 10, 20 μg	Standard rodent chow	Dark cycle	No effect	Chapman et al. 76

Note: Lowercase x indicates that the experimental detail could not be found.

^a Hyperphagia was not observed until 4 h post injection.