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. 2024 Aug 8;13(1):A0151. doi: 10.5702/massspectrometry.A0151

Table 1. MS/MS conditions for choline-containing compounds.

A. SRM parameters and the retention time

Compound Category Q1
(m/z)
Q3
(m/z)
DP
(V)
EP
(V)
CE
(V)
CXP
(V)
Retention time (min)
Choline Analyte 104 58 40 10 39 8 4.65
Acetylcholine Analyte 146 87 20 10 19 4 4.23
Betaine Analyte 118 58 20 10 37 12 4.89
Phosphocholine Analyte 184 125 200 10 25 14 6.11
Glycerophosphocholine Analyte 258 104 20 10 23 12 5.84
LPC (sn-1, 16:0) Analyte 496 184 160 6 31 10 3.77
LSM (d18:1/18:0) Analyte 465 184 140 4 29 8 4.69
Choline-2H9 IS 113 66 30 6 35 12 4.65
Betaine-2H11 IS 129 68 36 8 23 14 4.89
Phosphocholine-2H9 IS 193 95 20 10 23 6 6.10
Glycerophosphocholine-2H9 IS 267 113 20 8 23 26 5.84
LSM (d18:1/17:0) IS 451 184 120 6 27 12 4.66

CE, collision energy; CXP, cell exit potential; DP, declustering potential; IS, internal standard; LPC, lysophosphatidylcholine; LSM, lysosphingomyelin; MS/MS, tandem mass spectrometry; SRM, selected reaction monitoring.