The differential efficacy of NAT ligands and their Fe(iii), Cu(ii), and Zn(ii) complexes relative to Dp44mT and DpC to inhibit proliferation (IC₅₀; μM) of KBV1 (+Pgp) and KB31 (−Pgp) cells after incubations of 24, 48, or 72 h/37 °C. The results are mean ± SD (3 experiments).

Compounds	IC50 values (μM)
	24 h		Fold dif.	48 h		Fold dif.	72 h		Fold dif.
	KBV1	KB31		KBV1	KB31		KBV1	KB31
Dp44mT	2.39 ± 0.12	8.16 ± 0.88	3.42	0.23 ± 0.01	2.45 ± 0.24	10.54	0.01 ± 0.002	0.13 ± 0.02	10.68
DpC	1.31 ± 0.09	10.23 ± 0.7	7.82	0.16 ± 0.01	1.0 ± 0.05	6.71	0.19 ± 0.02	0.29 ± 0.07	1.53
AOBP	2.12 ± 0.30	11.16 ± 1.04	5.12	0.74 ± 0.02	4.56 ± 0.32	6.19	0.61 ± 0.06	0.97 ± 0.22	1.60
[Fe(AOBP)2]+	10.93 ± 0.98	14.75 ± 1.98	1.35	0.40 ± 0.02	3.78 ± 0.75	9.42	0.25 ± 0.02	1.94 ± 0.24	7.68
[Cu(AOBP)2]	2.13 ± 0.37	8.39 ± 0.98	3.95	0.26 ± 0.03	10.39 ± 0.52	39.72	0.14 ± 0.02	1.63 ± 0.34	11.66
[Zn(AOBP)2]	3.25 ± 0.42	>25	>7.7	0.59 ± 0.01	4.74 ± 0.54	7.96	0.37 ± 0.08	2.78 ± 0.16	7.43
AODP	5.75 ± 0.42	6.49 ± 0.86	1.13	0.55 ± 0.01	2.27 ± 0.31	4.09	0.46 ± 0.04	2.13 ± 0.22	4.61
[Fe(AODP)2]+	15.78 ± 1.97	17.66 ± 0.96	1.12	0.22 ± 0.03	5.23 ± 0.41	23.59	0.30 ± 0.010	2.40 ± 0.41	7.95
AOAPZ	5.43 ± 0.33	5.14 ± 0.86	0.95	1.32 ± 0.06	4.43 ± 0.39	3.36	1.42 ± 0.26	3.55 ± 0.51	2.49
[Cu(AOAPZ)2]	3.89 ± 0.18	3.73 ± 0.32	0.96	2.49 ± 0.05	3.64 ± 0.13	1.46	1.50 ± 0.19	2.84 ± 0.71	1.89
[Zn(AOAPZ)2]	12.13 ± 1.84	18.17 ± 2.46	1.49	0.63 ± 0.04	4.33 ± 0.45	6.85	0.69 ± 0.12	1.72 ± 0.18	2.47
AOAP	6.56 ± 0.74	7.95 ± 0.99	1.21	2.29 ± 0.18	4.62 ± 0.31	2.01	1.69 ± 0.33	2.12 ± 0.38	1.25
[Fe(AOAP)2]+	>25	>25	—	1.21 ± 0.22	19.58 ± 2.03	7.96	2.09 ± 0.39	>5	>2.38
[Cu(AOAP)2]	2.96 ± 0.38	4.21 ± 0.68	1.42	2.46 ± 0.06	3.23 ± 0.26	1.31	0.87 ± 0.161	2.56 ± 0.61	2.97