Non-Native Site-Selective Enzyme Catalysis

. Author manuscript; available in PMC: 2024 Aug 19.

Published in final edited form as: Chem Rev. 2023 Jul 31;123(16):10381–10431. doi: 10.1021/acs.chemrev.3c00215

Scheme 56. (A) General Scheme of the Native Prenyltransferase Reaction by Dimethylallyltryptophan Synthases (DMATSs) and Representative Non-Native Products for DMATSs with Different Site Selectivity;375,383 (B) Geranylation Reactions on Genistein (359) by AtaPT Single Mutants384.