TABLE 5.
Dual Stain Triage of HPV-Positive NILM, ASC-US, or LSIL Cytology Results in a Cotesting Setting in KPNC
| Current test result | N | % of Total | CIN3+ cases | CIN3+ immediate risk (%) |
CIN3+ 3-y cumulative risk (%) |
Clinical management recommendation | Management confidence probability% |
|---|---|---|---|---|---|---|---|
| HPV+/NILM/DS+ | 1,003 | 1.4 | 73 | 4.6 | 8.6 | Colposcopy | 79 |
| HPV+/NILM/DS− | 1,864 | 2.7 | 20 | 0.60 | 1.5 | 1-y return | 100 |
| HPV+/ASC-US/DS+ | 978 | 1.0 | 82 | 6.6 | 9.9 | Colposcopy | 100 |
| HPV+/ASC-US/DS− | 954 | 1.0 | 15 | 0.87 | 1.6 | 1-y return | 100 |
| HPV+/LSIL/DS+ | 942 | 0.9 | 46 | 4.1 | 5.9 | Colposcopy | 58 |
| HPV+/LSIL/DS− | 595 | 0.6 | 7 | 0.53 | 0.92 | 1-y return | 100 |
ASC-US indicates atypical squamous cells of undetermined significance; LSIL, low-grade intraepithelial lesion; NILM, negative for intraepithelial lesion or malignancy.