Table 1.
Characteristics of Patients With Invasive Group A Streptococcus Infection: Active Bacterial Core surveillance (2010–2012)
| Characteristic | Number (%) N = 2927 |
|---|---|
| Age group in years: | |
| 18–49 | 1102 (37.6) |
| 50–64 | 852 (29.1) |
| ≥65 | 973 (33.2) |
| Male gender | 1611 (55.0) |
| Race | |
| White | 2222 (75.9) |
| Black | 432 (14.8) |
| Other racea | 273 (9.3) |
| Body mass index (BMI) category | |
| Underweight (<18.5) | 131 (4.5) |
| Normal weight (18.5–<25.0) | 836 (28.6) |
| Overweight (25.0–<30.0) | 818 (27.9) |
| Obesity grade 1–2 (30.0–<40.0) | 743 (25.4) |
| Obesity grade 3 (≥40) | 399 (13.6) |
| Underlying conditions | |
| Diabetes | 859 (29.3) |
| Skin conditionsb | 836 (28.6) |
| Current smoker | 548 (18.7) |
| Heart disease | 544 (18.6) |
| Chronic renal disease/dialysis | 375 (12.8) |
| Immunosuppressionc | 310 (10.6) |
| Malignancyd | 303 (10.4) |
| Alcohol abuse | 277 (9.5) |
| Chronic obstructive pulmonary disease (COPD)/asthma | 272 (9.3) |
| Any underlying conditione | 2539 (86.7) |
| Primary syndromef | |
| Skin/soft tissue infectiong | 976 (33.3) |
| Bacteremia without a focus | 629 (21.5) |
| STSS/septic shock | 533 (18.2) |
| Pneumonia | 352 (12.0) |
| Necrotizing fasciitis | 123 (4.2) |
| Meningitis/other central nervous system infection | 29 (1.0) |
| Other syndrome | 314 (10.7) |
| emm typesh | |
| emm1 | 480 (16.4) |
| emm89 | 222 (7.6) |
| emm12 | 195 (6.7) |
| emm28 | 140 (4.8) |
| emm3 | 139 (4.7) |
| Other emm types | 1062 (36.3) |
| emm type unknown | 689 (23.5) |
Abbreviation: STSS, streptococcal toxic shock syndrome.
Includes American Indian/Alaska Natives (6.0%) and Asian/Other Pacific Islanders (3.3%).
Skin condition includes chronic skin breakdown or recent (within 7 days of culture) varicella infection, penetrating or blunt trauma, surgical wound or burn.
Includes patients with immunoglobulin deficiencies, nephrotic syndrome, organ transplantation, receipt of immunosuppression therapy, AIDS and asplenia.
Excludes malignancies of the skin.
Includes conditions listed and other underlying conditions.
Patients with more than one syndrome were categorized into the most severe one based on the likelihood of death for patients with a single syndrome.
Skin/soft tissue infection includes cellulitis, erysipelas, wound infections, phlebitis, lymphangitis, lymphadenitis and gangrene but excludes necrotizing fasciitis.
Five most common emm types are listed individually.