Fig. 4.

AuCeNPs attenuates hypoxic pulmonary vasoconstriction. Isometric tension of endothelium removed pulmonary artery (PA) rings preconstricted by phenylephrine (PE) in response to acetylcholine (Ach) and two sequential episodes of hypoxia (hy1 and hy2) followed by a final exposure of 80 mM K⁺ (KCl physiological salt solution (KPSS) in the presence of the vehicle (A), CeNPs at 10 µg/mL (B) or AuCeNPs at 10 µg/mL (C) added during the second episode of hypoxia (hy2), normalized to the tension induced by KPSS (***p < 0.001, *p < 0.05, n = 3, D). One-way ANOVA followed by Student-Newman-Keuls for multiple groups comparisons