Fig. 6.

AuCeNPs reverses hypoxia-induced pulmonary hypertension. The experimental schematic to evaluate the effect of AuCeNPs on hypoxic pulmonary hypertension in therapeutic mode (A). Changes in parameters including mean pulmonary artery pressure (mPAP, B), pulmonary vascular resistance (PVR, C), right ventricle hypertrophy (RV/[LV + S], D), mean systemic arterial pressure (mSAP, E), representative HE staining (F) and pulmonary vascular wall thickness (pulmonary arteries with diameter 50–100 μm, G) in rats, and malondialdehyde (MDA, H), 8-hydroxydeoxyguanosine (8-OHdG, I) in pulmonary arteries of rats treated with vehicle, CeNPs or AuCeNPs under normoxic or hypoxic conditions. n = 5 rats in each group, ***p < 0.001, **p < 0.01, *p < 0.05, one-way ANOVA followed by Student-Newman Keuls. LV + S indicates left ventricle plus septum