Fig. 5.

Clonal hierarchies of events in patients with aberrations in chromosome 7. A Clonality analysis of SNV and CNV events derived from the CCFs calculated using ASCAT [69] and CNACS [47] data in the exploration cohort (n = 60 paired diagnosis/remission samples). x/xLOH represents a chromosome or arm level CNV, and del(xp) or del(xq) represents the deletion of any part of the respective p or q arm. B Plot shows SNV acquisition order resulting from a Bradley–Terry model applied to mutation pairs, using the CCF calculated by correction of sample purity, ploidy, and CNV/cnLOH presence determined in pureCN (depicted on the left) in n = 342 patients. The number of mutations that entered the model is reported for each gene. To the right, the points correspond to point estimations, and the bars represent the 95% confidence intervals. Early mutations have high estimations, thus their points are arranged on the left. The median point estimation value is taken as a reference point for early versus late distinctions (grey arrow). Genes are color-coded by their assumed functional category