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. 2024 Jul 25;41:336–354. doi: 10.1016/j.bioactmat.2024.07.024

Fig. 7.

Fig. 7

(A) CLSM observation of ROS, GPX4, Clacein-AM; scale bar: 50 μm; The quantitative analysis of (B) ROS, (C) GPX4 and (D) Clacein-AM under conditioned culture; (E)Volcano plot of differential genes in Ti-PCA-DFO group compared with Ti group; (F) Cluster analysis of differentially expressed genes; (G) The main reactome pathways of differentially expressed genes; (H) KEGG and (I) GO enrichment analysis of DGs; (J) Heatmap of the DGS related to ferroptosis; (K) PPI network analysis of DGs and the core genes; Representative western blotting images (L) and quantitative analysis (M, N) of SLC7A11, GPX4, HMOX1; (O) The molecular docking of the core genes (SLC7A11, GPX4, HMOX1) and DFO. n = 3, *p <0.05, **p <0.01, ***p < 0.001, ****p < 0.0001.