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. 2024 Aug 19;43:232. doi: 10.1186/s13046-024-03111-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — TG-101,209 increased tumor response to chemotherapeutic agents. (A) Subcutaneous growth of mice in the control group, single-drug, two-drug combination, and TG-101,209 in combination with two traditional drugs groups (n = 6). (B) The volume change of nude mice implanted tumors was recorded every 3 days. Each bar represents the mean ± SD for six animal measurements. (C) The K-M survival analysis in different chemotherapy drug treatment groups was performed until the sacrifice of mice. Tumor cell lines were transplanted to the liver in situ of mice. (D) CCK-8 assay was performed to determine the cell viability after treatment in MCF-7, A-549, SW480, and Hep-G2 cell lines. (E) Representative ki67 and 4-6‐Diamidino‐2‐phenylindole (DAPI) immunofluorescence staining of tumor sections from the tumor tissues in different treatment groups. (F) Three-dimensional stereo thermograms showing synergistic promotion between two-by-two drugs. * P < 0.05, **P < 0.01 or *** P < 0.001