Table 3. Operating characteristics of the continuous reassessment model.
Starting dose level 1, dose-skipping not allowed, 3 dose levels, maximum 24 participants.Skeleton (a priori probabilities of DLE) = 0.05, 0.11, 0.20target DLE rate=no greater than 20% | |||
Dose level | |||
1 | 2 | 3 | |
Scenario 1: recommendation (%) | 2.5 | 24.5 | 73.0 |
Scenario 2: recommendation (%) | 22.5 | 46.5 | 31.0 |
Scenario 3: recommendation (%) | 0.0 | 3.3 | 96.7 |
Scenario 1: true probabilities=a priori probabilitiesScenario 2: true probabilities=0.10, 0.20, 0.30Scenario 3: true probabilities=0.02, 0.05, 0.10 |
DLEdose-limiting event