Figure 6. (A) Principal component analysis that relates the variables of Extracellular Vesicle (EV) size, phenotype and SLEDAI in patients with SLE without nephritis (SLE-nLN), Lupus Nephritis (SLE-LN) and controls (Ctrls). (B) Receiver operating characteristic (ROC) curve of large EV plasma concentrations for SLE, LN and nLN subjects. (C) ROC curve of EV-IgM+ for SLE, LN and nLN subjects. AUC, area under the curve; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index 2K.