Figure 1. CONSORT flow diagram. Stage I: Initial item generation through content analysis of cough descriptors in 1-2-1 interviews. Stage II: Cognitive debrief of cough descriptors in focus group discussions, split by diagnosis. The most articulate and agreed on items comprised the draft TOPIC questionnaire. Stage III: Participants from respiratory cough clinics completed the draft-TOPIC questionnaire. CF, cystic fibrosis; CONSORT, consolidated standards of reporting trials; COPD, chronic obstructive pulmonary disease; ILD, interstitial lung disease; RUCC, refractory/unexplained chronic cough; TOPIC, the sensations and triggers provoking cough.