Table 3. Parotid gland biopsy results.

	PedSjDn=19	Diagnostic adSjDn=32	PedSjD versus diagnostic adSjDP value	Trial adSjDn=42	PedSjD versus trial adSjDP value
Focus score*	2.6 (1.3–3.4)	1.1 (0.3–1.8)†	0.003	1.82 (1.2–4.67)	0.79
Focus score ≥1, n (%)	16 (84.2)	21 (65.6)	0.20	36 (85.7)	1.00
CD45+ cells* (% of parenchyma)	20.4 (9.3–35)	10.35 (2.26–24.01)	0.041	16.3 (4.9–28.9)	0.46
LELs/mm2*	0.00 (0.00–0.29)	0.14 (0.00–0.26)	0.94	0.08 (0.00–0.35)	0.79
Presence of LELs, n (%)	9 (48)	18 (56)	0.54	23 (56)	0.53
LEL severity (1–3)*	2 (1–3)	2 (1–3)	0.87	1 (1–2)	0.27
CD21+ FDC networks/mm2*	0.21 (0.06–0.79)†	0.00 (0.00–0.35)	0.029	0.21 (0.00–0.46)	0.28
Bcl6+ ectopic GC/mm2*	0.14 (0.04–0.33)	0.00 (0.00–0.12)	0.002	0.00 (0.00–0.24)	0.018
CD3+ cells/mm2*	1384 (841–1883)	470 (177–1406)	0.029	715 (256–1917)	0.15
CD20+ cells/mm2*	1679 (428–2811)	376 (61–1003)	0.004	624 (108–1300)	0.023
CD20/(CD20+CD3) ratio*	0.51 (0.32–0.58)	0.39 (0.25–0.48)	0.013	0.40 (0.23–0.50)	0.023
CD3/CD20 segregation, n (%)	14 (74)	18 (56)	0.21	24 (57)	0.22
IgA/IgG plasma cell shift, n (%)	9 (47)	18 (56)	0.54	24 (57)	0.48
IgM+plasma cells/mm2*	68 (25–156)	42 (10–93)	0.09	29 (6–93)	0.007

Significant p values are italicised and bold.

^*Data are reported as median (IQR) or n (%).

^†Missing data: 0–5.

adSjDadult-onset Sjögren’s diseaseFDCfollicular dendritic cellGCgerminal centreIgAimmunoglobulin ALELlymphoepithelial lesionmm2square millimetrePedSjDpaediatric-onset Sjögren’s disease