Fig. 6.

Insulin secretion responses to non-metabolizable GPR40 agonists

A–D) Representative perifusions (number of repeats N = 3–5, see panels E,F), demonstrating the stimulation of insulin secretion at 5.5 mM glucose with GPR40-agonists CAY10587 (10 μM, black edge symbols) and Agonist II (1 μM, violet) in wt (B) and iPLA₂γKO-PIs (green, green edge) (A,C,D) in the absence and presence of 5 μM nimodipine (yellow) (B,C), and 2.5 μM etomoxir (dark red) (D). Panels (E,F) summarize the respective yielded AUCs relative to Agonist-II assay with no other agents.