FASIS at extended period in vivo compared to GSIS Backcrossed wt mice: black; iPLA2γKO mice: green.
A–C,G,H) Oral administration of Intralipid (10 μl g−1; n = 54 for wt or KO) was performed at time zero. Each mice was sampled for blood insulin, c-peptide, and glycemia three times and time courses were constructed from different times of different mice. D–F) i.p. administration of glucose (1 mg/g body weight; ∼111 μmol glucose per mouse. The groups of mice investigated are indicated with different symbols. ANOVA: *P < 0.05; **P < 0.01; ***P < 0.001.