Fig 1.

BBR combined with EDTA can significantly restore colistin sensitivity against colistin-resistant Salmonella and E. coli. (A) Fold change in MIC of COL in different strains after combination with BBR and EDTA. The bar graphs show the MIC values of COL for the tested bacterial strains when combined with 1/2 MIC of BBR and 1/2 MIC of EDTA or both. (B) Time-dependent killing curves of strains SB05 and CS01 treated with COL, BBR, and EDTA. One-half MICs of BBR for the two strains were both 625 mg/L; one-half MICs of EDTA for SB05 and CS01 were 125.0 and 62.5 mg/L, respectively. (C) Colonies on LB agar plates at the indicated time point in the time-dependent killing curve of Salmonella SB05 with COL of 2 mg/L.