Table 3.
Patient characteristics | Events (n) | Person- years | 5-year Cumulative incidence (%)a | p b | Crude | Adjusted | ||
---|---|---|---|---|---|---|---|---|
Hazard ratio (95% CI) | p c | Hazard ratio (95% CI) | p c | |||||
Haematological cancers | ||||||||
Diagnostic periodd | 0.20 | 0.20 | 0.20 | |||||
2001–2010 | 39 | 2,973 | 5.9 (4.2, 7.8) | Reference | Reference | |||
2011–2021 | 26 | 2,649 | 4.3 (2.9, 6.1) | 0.70 (0.43, 1.15) | 0.70 (0.43, 1.15) | |||
Linear trend per year | 65 | 5,622 | 0.98 (0.94, 1.03) | 0.50 | 0.99 (0.94, 1.03) | 0.50 | ||
Sexe | < 0.01 | < 0.01 | 0.01 | |||||
Female | 38 | 2,346 | 7.1 (5.1, 9.4) | Reference | Reference | |||
Male | 27 | 3,277 | 3.6 (2.4, 5.1) | 0.50 (0.31, 0.83) | 0.52 (0.32, 0.85) | |||
Age groupsf | < 0.01 | 0.01 | 0.02 | |||||
Below 1 year | 8 | 219 | 13.0 (6.2, 23.0) | 2.96 (1.36, 6.43) | 2.72 (1.25, 5.92) | |||
1–5 years | 32 | 2,849 | 4.9 (3.4, 6.8) | Reference | Reference | |||
6–10 years | 18 | 1,338 | 6.1 (3.7, 9.2) | 1.20 (0.67, 2.13) | 1.26 (0.71, 2.24) | |||
11–14 years | 7 | 1,216 | 2.5 (1.1, 4.9) | 0.51 (0.23, 1.16) | 0.52 (0.23, 1.17) | |||
Relapseg | < 0.01 | < 0.01 | < 0.01 | |||||
No | 49 | 5,348 | 4.3 (3.2, 5.6) | Reference | Reference | |||
Yes | 16 | 274 | 10.0 (6.1, 16.0) | 22.9 (11.60, 45.10) | 21.20 (9.55, 47.20) | |||
Stem cell transplanth | 0.11 | < 0.01 | 0.07 | |||||
No | 53 | 5,103 | 4.7 (3.5, 6.0) | Reference | Reference | |||
Yes | 12 | 519 | 7.7 (4.3, 12.0) | 5.66 (2.82, 11.40) | 2.22 (0.95, 5.18) | |||
CNS involvementi | 0.02 | 0.04 | 0.05 | |||||
No | 57 | 5,325 | 4.7 (3.6, 6.0) | Reference | Reference | |||
Yes | 8 | 297 | 11.0 (4.9, 19.0) | 2.36 (1.13, 4.95) | 2.28 (1.06, 4.90) | |||
CNS tumours | ||||||||
Diagnostic periodd | 0.40 | 0.40 | 0.30 | |||||
2001–2010 | 9 | 1,666 | 2.3 (1.1, 4.1) | Reference | Reference | |||
2011–2021 | 7 | 1,768 | 1.5 (0.7, 2.9) | 0.64 (0.24, 1.73) | 0.62 (0.23, 1.66) | |||
Linear trend per year | 16 | 3,434 | 0.96 (0.88, 1.04) | 0.30 | 0.96 (0.88, 1.04) | 0.30 | ||
Sexe | 0.12 | 0.12 | 0.11 | |||||
Female | 11 | 1,686 | 2.6 (1.4, 4.4) | Reference | Reference | |||
Male | 5 | 1,748 | 1.1 (0.4, 2.5) | 0.44 (0.15, 1.27) | 0.43 (0.15, 1.25) | |||
Age groupsf | 0.04 | 0.06 | 0.06 | |||||
Below 1 year | 4 | 250 | 5.6 (1.8, 13.0) | 2.74 (0.80, 9.36) | 2.79 (0.82, 9.55) | |||
1–5 years | 7 | 1,268 | 2.2 (1.0, 4.3) | Reference | Reference | |||
6–10 years | 4 | 1,087 | 1.5 (0.5, 3.5) | 0.67 (0.20, 2.28) | 0.67 (0.20, 2.31) | |||
11–14 years | 1 | 829 | 0.5 (0.1, 2.5) | 0.22 (0.03, 1.77) | 0.21 (0.03, 1.71) | |||
Solid tumours | ||||||||
Diagnostic periodd | 0.60 | 0.60 | 0.60 | |||||
2001–2010 | 5 | 2,399 | 0.9 (0.4, 2.0) | Reference | Reference | |||
2011–2021 | 7 | 2,219 | 1.3 (0.6, 2.5) | 1.39 (0.44, 4.39) | 1.39 (0.44, 4.39) | |||
Linear trend per year | 12 | 4,618 | 1.05 (0.95, 1.16) | 0.30 | 1.05 (0.95, 1.16) | 0.30 | ||
Sexe | 0.50 | 0.50 | 0.50 | |||||
Female | 5 | 2,327 | 0.9 (0.6, 2.0) | Reference | Reference | |||
Male | 7 | 2,291 | 1.3 (0.6, 2.6) | 1.44 (0.46, 4.55) | 1.44 (0.45, 4.57) | |||
Age groupsf | 0.30 | 0.13 | 0.14 | |||||
Below 1 year | 3 | 1,061 | 1.2 (0.4, 3.3) | 0.78 (0.20, 3.13) | 0.75 (0.19, 3.01) | |||
1–5 years | 6 | 1,579 | 1.6 (0.7, 3.3) | Reference | Reference | |||
6–10 years | 0 | 932 | – | – | – | |||
11–14 years | 3 | 1,047 | 1.2 (0.3, 3.2) | 0.76 (0.19, 3.04) | 0.79 (0.20, 3.17) | |||
Stem cell transplanth | < 0.01 | < 0.01 | < 0.01 | |||||
No | 7 | 4,347 | 0.7 (0.3, 1.4) | Reference | Reference | |||
Yes | 5 | 270 | 5.8 (2.1, 12.0) | 41.80 (8.04, 217.00) | 46.90 (8.60, 256.00) | |||
Metastasisg | 0.01 | 0.01 | 0.02 | |||||
No | 5 | 3,598 | 0.6 (0.2, 1.4) | Reference | Reference | |||
Yes | 7 | 1,019 | 2.5 (1.1, 4.9) | 4.22 (1.34, 13.30) | 4.09 (1.30, 12.90) |
All analyses were implicitly adjusted for time since diagnosis (underlying timescale).
5-year cumulative incidence (%) with 95% confidence intervals
Gray’s Test
Likelihood ratio test
Adjusted for age at diagnosis and sex
Adjusted for year of diagnosis and age at diagnosis
Adjusted for year of diagnosis and sex
Adjusted for year of diagnosis, age at diagnosis, sex and stem cell transplant (time-dependent)
Adjusted for year of diagnosis, age at diagnosis, sex and relapse (time-dependent)
Adjusted for year of diagnosis, age at diagnosis and sex. CNS: central nervous system.