Table 2.

Influence of pre-specified variables on the endpoint, determined using Generalized Estimating Equations.

Variable	Cisplatin		Carboplatin
	p	Hazard ratio	p	Hazard ratio
Age	< 0.001	1.061	< 0.001	1.026
Gender	0.011	2.163	0.188	1.179
Dosage	0.245	0.995	0.052	0.999
Tumor type	< 0.001	#	0.016	#
Treatment goal	0.378	0.764	0.156	0.793
Baseline eGFR	< 0.001	1.083	< 0.001	0.994
Cycle number	0.147	0.926	< 0.001	0.847
Interval between renal function assessment and administration	0.552	0.994	0.049	0.996

^#depending on tumor type relative to reference tumor type (ref. cisplatin head neck, ref. carboplatin lung).