Table 2.

Multivariable models combining self-reported race/ethnicity, family history, and Agent Orange exposure for three PCa clinical endpoints.

Clinical Endpoint	Self-Reported Race/Ethnicity							Family History	Agent Orange Exposure
	Black or African American	Hispanic White	Asian	Native American	Pacific Islander	Unknown	Other
Fatal Prostate Cancer	2.34 [1.87–2.88]**	1.06 [0.53–1.6]	0.26 [0.0–0.8]	0.77 [0.0–1.86]	NA	NA	2.02 [1.04–3.17]	1.89 [1.45–2.34]*	1.02 [0.83–1.23]
Metastatic Prostate Cancer	2.49 [2.26–2.72]***	1.24 [0.97–1.52]	1.03 [0.55–1.53]	0.98 [0.52–1.49]	0.56 [0.0–1.42]	1.78 [0.77–3.13]	1.44 [1.06–1.86]	1.51 [1.34–1.7]**	1.07 [0.98–1.17]
Prostate Cancer	2.2 [2.13–2.26]***	1.02 [0.95–1.1]	0.87 [0.75–1.0]	1.02 [0.9–1.14]	0.89 [0.62–1.18]	0.83 [0.62–1.05]	1.05 [0.95–1.15]	1.85 [1.79–1.92]***	1.06 [1.04–1.09]*

Cox proportional hazards results for association with age at death from PCa, age at diagnosis of metastatic PCa, and age at diagnosis with PCa. P-values reported are from multivariable models using self-reported race/ethnicity, family history, and Agent Orange exposure (yes or no). Hazard ratios for race/ethnicity were estimated using Non-Hispanic White as the reference. Hazard ratios for family history were for one or more first-degree relatives diagnosed with prostate cancer. This multivariable analysis was limited to the 213,856 participants who were on active duty during the Vietnam War and for whom family history information was available. Numbers in brackets are 95% confidence intervals. Significant predictors in the multivariable model are indicated by

^*(p < 0.01),

^**(p < 10^-10), and

^***(p < 10^-16).