In vitro antiproliferative activities of the target compounds 5a–p.

Compound	R1	R2	Ar	IC50 (μM)
				MCF7	SKOV3	U87
5a	Br	H	Phenyl	1.90	1.38	1.08
5b	H	Br	Phenyl	1.11	2.99	2.00
5c	Br	H	p-F-phenyl	2.44	2.35	2.60
5d	H	Br	p-F-phenyl	1.84	1.98	6.61
5e	Br	H	p-Br-phenyl	3.82	3.06	2.83
5f	H	Br	p-Br-phenyl	1.86	4.36	2.24
5g	Br	H	2-Naphtyl	0.03	1.22	0.22
5h	H	Br	2-Naphtyl	0.32	0.51	0.93
5i	Br	H	p-OMe-phenyl	2.02	1.84	4.23
5j	H	Br	p-OMe-phenyl	1.56	1.78	1.28
5k	Br	H	p-Cl-phenyl	1.40	1.63	1.97
5l	H	Br	p-Cl-phenyl	3.22	1.13	1.56
5m	Br	H	p-Biphenyl	1.65	19.8	2.38
5n	H	Br	p-Biphenyl	0.11	1.93	1.97
5o	H	Br	p-Me	4.08	2.16	2.84
5p	Br	H	p-Me	2.29	2.01	2.11
Doxorubicin				0.50	1.76	0.31