Extended Data Fig. 11 |. RNA/DNA-bound MapSPARTA dimers.

a, Local resolutions of MapSPARTA dimer in mixed states.

b, FSC curves of reconstructed MapSPARTA dimer in mixed states.

c, Local resolutions of MapSPARTA asymmetric dimer.

d, FSC curves of reconstructed MapSPARTA asymmetric dimer.

e, Overlaid structures of asymmetric dimer (green) and that (grey) in the tetramer, revealing their similarity.

f, Symmetric dimer fitted into cryo-EM map.

g, E134R, disrupting MID-MID interactions, eluted as monomers in the presence of RNA/DNA.

h, MapSPARTA eluted as monomer in the presence of RNA.